Carolina Digestive Health Associates, PA
 

Cancer

Taking Part in CML Trials


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Summary & Participants

Hear one woman's story as she participates in a clinical trial to help fight CML.

Medically Reviewed On: July 11, 2008

Webcast Transcript


BETTY: People were really surprised that I didn't get referred by a doctor. They say, "Okay, your doctor didn't refer you there?" "No. I just found out about it by myself." And I've told people that you can't wait for the doctor to decide to tell you, "Okay, go here or go there." You have to research it yourself.

ANNOUNCER: Betty lives an hour away from the University of California at Los Angeles Medical Center, and she called up, inquiring about clinical trials. She spoke with the coordinator of a trial for one of two drugs being evaluated for effectiveness in cases of resistance to Gleevec.

BETTY: I was really happy to find out that there was a trial going on, and that I would probably be eligible for it, and given what my doctor had said, that that would be the next best thing. I thought, "Oh, this is great. It's going to come along at the right time."

ANNOUNCER: It was a Phase II trial, testing high doses of Gleevec against a new drug called dasatinib now also called Sprycel, for patients whose disease developed resistance to Gleevec on the standard dose. Betty was randomly assigned to the new drug, and the initial results were quite good.

NEIL SHAH, MD, PhD: So she had an immediate, complete hematologic response, and we were able to remove her hydroxyurea, and that was the first sign that we were actually controlling her disease. And she subsequently has had bone marrow biopsies which have shown a complete cytogenetic remission, which is really very exciting, that we can take patients who otherwise have very few options to control their disease and get it back into a remission state that's pretty much as good as anything Gleevec could accomplish. So she's now in what we would call a complete cytogenetic remission.

BETTY: I called everybody and told them and called my husband, and I was crying. I said, you know, "Guess what?" So I was really, and still am surprised to this day that it's doing so good.

ANNOUNCER: The drug was not without complications. Betty has experienced shortness or breath and weakness. About 10 percent of patients develop some buildup of fluid around the lung.

NEIL SHAH, MD, PhD: Recently she has developed a little bit of fatigue, which we're in the process of trying to figure out. But my suspicion is it may be related to some of this fluid collection around the lung, and we're going to be investigating that a little bit further and doing any necessary procedures to hopefully not only treat that but prevent it from recurring.

ANNOUNCER: Betty's story illustrates how patients may sometimes do best when they take the initiative when it comes to clinical trials.

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